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Aug
Pathophysiology Of Short Bowel Syndrome. Intestinal resection can result in short bowel syndrome sbs due to reduction of total and or site specific nutrient processing areas. The two influences are discussed which have stimulated interest in short bowel syndrome over the last decade led to improvements in the conceptualization of its pathophysiology and resulted in a more rational basis for treatment. Physiologic derangements in short bowel syndrome are the result of the loss of large amounts of intestinal absorptive surface area. Clinical disease is only weakly correlated with the amount of intestine that is resected because of the highly variable length of the human small bowel and the remarkable ability of the bowel to compensate for bowel resection.
Short bowel syndrome sbs refers to a condition in which patients exhibit malabsorption induced diarrhea dehydration electrolyte disturbances and malnutrition due to poor nutrient processing capability resulting from extensive surgical resection of the intestine. Dehydration means the body lacks enough fluid and electrolytes chemicals in salts including sodium potassium and chloride to work properly. Depending on the segment s of intestine resected malabsorption can be nutrient specific eg vitamin b 12 or fat or sweeping with deficiencies in energy protein and various micronutrients. Diarrhea can lead to dehydration malnutrition and weight loss. Clinical disease is only weakly correlated with the amount of intestine that is resected because of the highly variable length of the human small bowel and the remarkable ability of the bowel to compensate for bowel resection. Short bowel syndrome sbs is a leading cause of intestinal failure if.
The main symptom of short bowel syndrome is diarrhea loose watery stools.
Home parenteral nutrition hpn remains the standard treatment with small intestinal transplantation reserved for cases with severe complications to hpn. The final common etiologic factor in all causes. The small intestine is where the majority of the nutrients you eat are absorbed into your body during digestion. 1 2 intestinal failure occurs when intestinal function is insufficient to meet the body s nutrition and hydration needs and supplementary parenteral nutrition and or intravenous fluid pn iv support is required. Short bowel syndrome can occur when. The two influences are discussed which have stimulated interest in short bowel syndrome over the last decade led to improvements in the conceptualization of its pathophysiology and resulted in a more rational basis for treatment.